Skin epithelial stem cells can be used to repair the cornea
2025-07-20 06:38:06
Limbal stem cell transplantation has long faced challenges due to limited donor availability and the risk of allogeneic rejection, which restricts its effectiveness for many patients. In an interview on the 7th, an official from the State Key Laboratory of Ophthalmology at Sun Yat-Sen University highlighted that recent research published in *Nature* by scholars from the university demonstrates a promising alternative: skin epithelial stem cells or other cell types can be efficiently and cost-effectively converted into sufficient quantities of limbal stem cells through differentiation and amplification. This breakthrough could provide a reliable source for repairing and regenerating the corneal surface, offering new hope for patients with limbal stem cell deficiencies.
On July 2, 2014, *Nature* published a major breakthrough in the joint research between Chinese and American scientists on stem cell therapy for corneal diseases. The study identified WNT7A and PAX6 as key regulators in the differentiation of limbal stem cells, playing a crucial role in guiding skin stem cells to transform into functional limbal stem cells. This process successfully restored corneal function, opening up a new strategy for treating corneal diseases and improving outcomes for patients suffering from related conditions.
The lead researcher emphasized that this discovery holds significant potential for treating major diseases caused by impaired limbal stem cell function, as well as for addressing postoperative epithelial damage following refractive surgeries like myopia correction. With further development, this approach could revolutionize the treatment landscape and bring more effective solutions to patients worldwide.
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